3,3-Dimethylbutanoyl chloride → 2-[4-(2-Neopentyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethyl 3,3-dimethylbutanoate

HRID 858394Notes

Reaction equation

HRID 858394 reaction equation
[NH2:1][C:2]1[C:3]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][OH:19])=[CH:13][CH:12]=2)=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8].[C:20]([CH2:24][C:25](Cl)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[CH3:21][C:20]([CH3:23])([CH3:22])[CH2:24][C:25]([O:19][CH2:18][CH2:17][C:14]1[CH:15]=[CH:16][C:11]([N:10]2[C:3]3=[N:4][C:5]([CH3:9])=[CH:6][C:7]([CH3:8])=[C:2]3[N:1]=[C:25]2[CH2:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:12][CH:13]=1)=[O:26]

Participants

3

Reactant 2

HCID 815143,3-Dimethylbutanoyl chlorideHCID 218759922-{4-[(3-Amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol

Product 1

HCID 218760312-[4-(2-Neopentyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethyl 3,3-dimethylbutanoate

Procedure

The title compound was prepared according to the procedure described in step 5 of Example 1 from 2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol (step 4 of Example 1) and tert-butylacetyl chloride.

Sources & evidence

ORD record
ord-8e087b0eadeb414c99f6b9639fbc78fa
Source dataset
uspto-grants-2006_12
Patent number
US07148234B2

Reaction notes

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