4-Aminophenethyl alcohol → 2-{4-[(6-Chloro-5-methyl-3-nitro-2-pyridinyl)amino]phenyl}ethanol

HRID 858412Notes

Reaction equation

HRID 858412 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([CH3:11])=[C:4]([Cl:12])[N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=1>>[Cl:12][C:4]1[N:3]=[C:2]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][OH:22])=[CH:16][CH:15]=2)[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]=1[CH3:11]

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 122654282,6-Dichloro-3-methyl-5-nitropyridine

Product 1

HCID 218758502-{4-[(6-Chloro-5-methyl-3-nitro-2-pyridinyl)amino]phenyl}ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 34 from 2,6-dichloro-5-methyl-3-nitropyridine (Horn, U.; Mutterer, F.; Weis, C. D. Helv. Chim. Acta., 1976, 59,190.) and 4-aminophenylethyl alcohol.

Sources & evidence

ORD record
ord-49af00bf0df0420dac536a934d13561f
Source dataset
uspto-grants-2006_12
Patent number
US07148234B2

Reaction notes

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