反应详情

温度

50 °C

To a solution of diethyl 2-(2-chloro-4-nitrophenyl)malonate (step 1, 7.6 g, 24.2 mmol) in methanol (18 ml) was added 6M-NaOH (12 ml) and stirred for 1 h at 50° C. The reaction was quenched by the addition of saturated citric acid aqueous solution (16 ml) and water. The organic layer was extracted with ethyl acetate (2×50 ml), washed with brine, dried (MgSO4) and concentrated to give 4.52 g (87%) of title compound as light yellow solid.

1. customThe reaction was quenched by the addition of saturated citric acid aqueous solution (16 ml) and water
2. extractionThe organic layer was extracted with ethyl acetate (2×50 ml)
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated