HRID858514

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9837177

Isoquinoline-5-sulfonamide

C9H8N2O2S

结构：CCc1nc2cc(C(F)(F)F)c(Cl)cc2n1-c1ccc(CCOC(=O)Oc2ccccc2)cc1

HCID21876409

未命名化合物

PRODUCTS

生成物

结构：CCc1nc2cc(C(F)(F)F)c(Cl)cc2n1-c1ccc(CCOC(=O)NS(=O)(=O)c2cccc3cnccc23)cc1

HCID21876099

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in step 2 of Example 243 from 2-{4-[6-chloro-2-ethyl-5-(trifluoromethyl)-1H-benzimidazol-1-yl]phenyl}ethyl phenyl carbonate and 5-isoquinolinylsulfonamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e52dc22a9d25414298e288b6d685430d
来源数据集: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07148234B2
来源说明: uspto-grants-2006_12

反应 SMILES

[C:1](=O)([O:27]C1C=CC=CC=1)[O:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]3[CH:16]=[C:17]([Cl:24])[C:18]([C:20]([F:23])([F:22])[F:21])=[CH:19][C:14]=3[N:13]=[C:12]2[CH2:25][CH3:26])=[CH:7][CH:6]=1.[CH:35]1[C:44]2[C:39](=[C:40]([S:45]([NH2:48])(=[O:47])=[O:46])[CH:41]=[CH:42][CH:43]=2)[CH:38]=[CH:37][N:36]=1>>[Cl:24][C:17]1[C:18]([C:20]([F:23])([F:22])[F:21])=[CH:19][C:14]2[N:13]=[C:12]([CH2:25][CH3:26])[N:11]([C:8]3[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][O:2][C:1](=[O:27])[NH:48][S:45]([C:40]4[CH:41]=[CH:42][CH:43]=[C:44]5[C:39]=4[CH:38]=[CH:37][N:36]=[CH:35]5)(=[O:47])=[O:46])=[CH:10][CH:9]=3)[C:15]=2[CH:16]=1