反应详情

A solution of 2-oxo-1-pyrrolidinepropionitrile (22.4 g, 16.2 mmol), 15% NaOH solution (40 mL) and dioxane (40 mL) was heated under reflux for 5 h under N2. The reaction mixture was extracted with EtOAc. The aqueous layer was made acidic with 6N HCl amd extracted with CH2Cl2 (5×50 mL). The organic layers were dried over Na2SO4 and concentrated to give the title compound as a cream solid (12.4 g, 49%).

1. temperatureunder reflux for 5 h under N2
2. extractionThe reaction mixture was extracted with EtOAc
3. extractionamd extracted with CH2Cl2 (5×50 mL)
4. dry with materialThe organic layers were dried over Na2SO4
5. concentrationconcentrated