HCID 10431947, compound → HCID 10474324, compound

HRID 858574Notes

Reaction equation

HRID 858574 reaction equation
[C:1]([C:5]1([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][C:18]3([CH:26]4[CH2:30][CH2:29][CH2:28][CH2:27]4)[O:23][C:22](=[O:24])[CH2:21][C:20](=[O:25])[CH2:19]3)=[CH:12][CH:11]=2)OCC[O:6]1)([CH3:4])([CH3:3])[CH3:2]>CC(C)=O>[CH:26]1([C:18]2([CH2:17][CH2:16][C:13]3[CH:14]=[CH:15][C:10]([C:5](=[O:6])[C:1]([CH3:3])([CH3:2])[CH3:4])=[CH:11][CH:12]=3)[O:23][C:22](=[O:24])[CH2:21][C:20](=[O:25])[CH2:19]2)[CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 1

HCID 10431947HCID 10431947, compound

Product 1

HCID 10474324HCID 10474324, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 6-{2-[4-(2-tert-Butyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl}-6-cyclopentyl-dihydro-pyran-2,4-dione from Example A(34), . (0.173 g) in acetone (1 mL) was added Amberlyst 15 (0.05 g). The reaction mixture was stirred at room temperature overnight, and then filtrated. The solvent was removed under reduced pressure. The residue was purified by flash chromatography (40% EtOAc in Hexanes) to yield the product as a white foam (0.04 g, 95%).

Workup

  1. filtrationfiltrated
  2. customThe solvent was removed under reduced pressure
  3. customThe residue was purified by flash chromatography (40% EtOAc in Hexanes)

Sources & evidence

ORD record
ord-1be0a6eadf9d4ecaaf71662f74cc98e3
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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