HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-(4-Bromo-phenyl)-N-methyl-isobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Monoethyl malonate | HCID 70615 | — |
| Reactant | (R)-4-bromo-alpha-methylbenzylamine | HCID 853000 | — |
| Reactant | 2-(4-Bromophenyl)-2-methylpropanoic acid | HCID 10933679 | — |
| Product | 2-(4-Bromo-phenyl)-N-methyl-isobutyramide | HCID 58762757 | 84% |
Reaction Steps
The title compound was prepared as described in Step 1 of Example A(39), where 2-(4-bromophenyl)-2-methyl propionic acid was substituted for ethyl hydrogen malonate and methyl amine was substituted instead of (R)-(+)-1-(4-bromophenyl)ethylamine on that example. Yield 84%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148226B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-a025f88052e6471dbade514643702c64 |
| Source note | uspto-grants-2006_12 |