HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylsilane → 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 5-Bromo-2,3-dihydro-3,3-dimethyl-2-hydroxybenzofuran | HCID 20536224 | — |
| Reactant | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran | HCID 5323595 | — |
Reaction Steps
A solution of 5-Bromo-3,3-dimethyl-2,3-dihydro-benzofuran-2-ol (813 mg, 3.36 mmol), Triethylsilane (805 □L, 5.04 mmol), and 30% TFA/CH2Cl2 (15 mL), were stirred at room temperature for 1 h. The solution was then diluted with Toluene (15 mL), stripped of all solvents, and chromatographed on silica eluted with a gradient 5–25% Ethyl acetate/Hexanes. Yield 549 mg, 72%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148226B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-016d0070ac094b71acdf0328e0163ead |
| Source note | uspto-grants-2006_12 |