Aluminum(III) Chloride → HCID 58762268, compound

HRID 858716Notes

Reaction equation

HRID 858716 reaction equation
[CH:1]1([C:6]2([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH:23]([CH3:25])[CH3:24])=[C:18]([F:26])[CH:17]=3)[O:11][C:10](=[O:12])[CH2:9][C:8](=[O:13])[CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:27][C:28]1[CH:41]=[CH:40][C:31]2[N:32]([CH:37]([CH3:39])[CH3:38])[C:33]([CH:35]=O)=[N:34][C:30]=2[CH:29]=1.[Al+3].[Cl-].[Cl-].[Cl-]>>[Cl:27][C:28]1[CH:41]=[CH:40][C:31]2[N:32]([CH:37]([CH3:39])[CH3:38])[C:33]([CH2:35][C:9]3[C:10](=[O:12])[O:11][C:6]([CH:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)([CH2:14][CH2:15][C:16]4[CH:21]=[CH:20][C:19]([O:22][CH:23]([CH3:24])[CH3:25])=[C:18]([F:26])[CH:17]=4)[CH2:7][C:8]=3[OH:13])=[N:34][C:30]=2[CH:29]=1

Participants

4

Reactant 3

HCID 6451240Aluminum(III) ChlorideHCID 160761116-(3-fluoro-4-isopropoxyphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dioneHCID 508770585-Chloro-1-isopropyl-1H-benzoimidazole-2-carbaldehyde

Product 1

HCID 58762268HCID 58762268, compound

Procedure

The title compound was prepared by coupling 6-Cyclopentyl-6-[2-(3-fluoro-4-isopropoxy-phenyl)-ethyl]-dihydro-pyran-2,4-dione from Step 1 below to 5-Chloro-1-isopropyl-1H-benzoimidazole-2-carbaldehyde using the AlCl3/reduction procedure described in Example B(13). ESIMS (MH+): 570.3

Sources & evidence

ORD record
ord-59c76cb0b1fd489c9c202b85e981c5bf
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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