HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1H-Pyrazol-1-yl)benzaldehyde → 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(4-pyrazol-1-yl-benzyl)-5,6-dihydro-pyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1H-Pyrazol-1-yl)benzaldehyde | HCID 2776477 | — |
| Reactant | 6-(3-chloro-4-methoxyphenethyl)-6-cyclopentyl-dihydro-3H-pyran-2,4-dione | HCID 16076109 | — |
| Product | 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-4-hydroxy-3-(4-pyrazol-1-yl-benzyl)-5,6-dihydro-pyran-2-one | HCID 58762383 | — |
Reaction Steps
The title compound was prepared by coupling 6-[2-(3-Chloro-4-methoxy-phenyl)-ethyl]-6-cyclopentyl-dihydro-pyran-2,4-dione from Step 1 of Example B(13), to 4-Pyrazol-1-yl-benzaldehyde using the Me2NHBH3 method described in the synthesis of Example B(31).ESIMS (MH+): 508.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148226B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-23b2c862a0c14149bb9c4ff9d484afec |
| Source note | uspto-grants-2006_12 |