反应详情

An aqueous solution of NaOH (1 M, 270 mL) was added to a mixture of the 3-(4-benzyloxyphenyl)propionic acid methyl ester from Step 2 above in MeOH (600 mL) and the reaction was stirred overnight. The crystalline ppt was collected by filtration, air dried and then partitioned between EtOAc/Et2O/1 M HCl (500 mL, 250 mL, 150 mL). The organic phases were dried over MgSO4 and evaporated to give the product as a white solid (16.2 g, 70%, 3 Steps).

1. filtrationThe crystalline ppt was collected by filtration, air
2. customdried
3. custompartitioned between EtOAc/Et2O/1 M HCl (500 mL, 250 mL, 150 mL)
4. dry with materialThe organic phases were dried over MgSO4
5. customevaporated