HCID 58762400, compound → HCID 58762668, compound

HRID 858799Notes

Reaction equation

HRID 858799 reaction equation
Cl[C:2]1[C:3](=[O:29])[O:4][C:5]([CH:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([CH3:23])=[N:19][O:20][C:21]=3[CH3:22])=[CH:13][CH:12]=2)[CH2:6][C:7]=1[OH:8].[CH3:30][C:31]1[CH:36]=[C:35]([CH3:37])[N:34]2[N:38]=[C:39]([SH:41])[N:40]=[C:33]2[N:32]=1>>[CH:24]1([C:5]2([CH2:9][CH2:10][C:11]3[CH:16]=[CH:15][C:14]([C:17]4[C:18]([CH3:23])=[N:19][O:20][C:21]=4[CH3:22])=[CH:13][CH:12]=3)[O:4][C:3](=[O:29])[C:2]([S:41][C:39]3[N:40]=[C:33]4[N:32]=[C:31]([CH3:30])[CH:36]=[C:35]([CH3:37])[N:34]4[N:38]=3)=[C:7]([OH:8])[CH2:6]2)[CH2:25][CH2:26][CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 58762400HCID 58762400, compoundHCID 178426287HCID 178426287, compound

Product 1

HCID 58762668HCID 58762668, compound

Procedure

The title compound was prepared from 3-Chloro-6-cyclopentyl-6{2-[4-(3,5-dimethyl-isoxazol-4-yl)-phenyl]-ethyl}4-hydroxy-5,6-dihydro-pyran-2-one from Step 2 and 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol using the coupling method described in Example C(4).

Sources & evidence

ORD record
ord-ec01544e291744b5ba7a59f99ef971b2
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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