HCID 58762559, compound → HCID 58762617, compound

HRID 858802Notes

Reaction equation

HRID 858802 reaction equation
Cl[C:2]1[C:3](=[O:13])[O:4][C:5]([CH2:11][CH3:12])([CH2:9][CH3:10])[CH2:6][C:7]=1[OH:8].[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]2[N:22]=[C:23]([SH:25])[N:24]=[C:17]2[N:16]=1>>[CH3:14][C:15]1[CH:20]=[C:19]([CH3:21])[N:18]2[N:22]=[C:23]([S:25][C:2]3[C:3](=[O:13])[O:4][C:5]([CH2:11][CH3:12])([CH2:9][CH3:10])[CH2:6][C:7]=3[OH:8])[N:24]=[C:17]2[N:16]=1

Participants

3

Reactant 2

HCID 58762559HCID 58762559, compoundHCID 178426287HCID 178426287, compound

Product 1

HCID 58762617HCID 58762617, compound

Procedure

The title compound was prepared from 3-Chloro-6,6-diethyl-4-hydroxy-5,6-dihydro-pyran-2-one (from Step 1) and 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol using the coupling method described in Example C(4). 1H NMR (CDCl3): δ 0.97 (t, 6H, J=7.5 Hz), 1.85 (m, 2H), 1.94 (m, 2H), 2.63 (s, 3H), 2.71 (s, 3H), 2.78 (s, 2H), 6.78 (s, 1H). Anal. Calcd. For C16H20N4O3S.0.5H2O: C, 53.76; H, 5.92; N, 15.68. Found: C, 53.96; H, 5.84; N, 15.37.

Sources & evidence

ORD record
ord-7a8829f0ed4641ceafcb22f6d9202dfd
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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