Bromide ion → 4-Bromo-2-chloro-1-isopropoxybenzene

HRID 858807Notes

Reaction equation

[Br-].[Br:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([Cl:10])[CH:4]=1.Br[C:12]1[CH:17]=CC(O)=C(F)[CH:13]=1.IC(C)C.BrC(CC)C([O-])=O>>[Br:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH:12]([CH3:17])[CH3:13])=[C:5]([Cl:10])[CH:4]=1

Participants

Reactant 5

HCID 259Bromide ion

HCID 6362Isopropyl iodide

HCID 198594-Bromo-2-chlorophenol

HCID 1523172-Bromobutyrate

HCID 27249814-Bromo-2-fluorophenol

Product 1

HCID 219385904-Bromo-2-chloro-1-isopropoxybenzene

Procedure

The intermediate bromide, was prepared analogously to Step 1 in Example A(52), where 4-Bromo-2-chloro-phenol was substituted in place of 4-bromo-2-fluorophenol and 2-iodopropane instead of methyl □-bromobutyrate of that example.

Sources & evidence

ORD record: ord-f893d34951da4d5ba8bca53e209e6192
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07148226B2

Reaction notes

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