3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one → HCID 58762495, compound

HRID 858812Notes

Reaction equation

HRID 858812 reaction equation
Cl[C:2]1[C:3](=[O:23])[O:4][C:5]([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:6][C:7]=1[OH:8].ClC1C(=O)OC(CCC2CCCCC=2)(C2CCCC2)CC=1O.[Cl:46][C:47]1[CH:59]=[CH:58][C:50]2[N:51]([CH:55]([CH3:57])[CH3:56])[C:52]([SH:54])=[N:53][C:49]=2[CH:48]=1.N1C=CC(C2NC(S)=NN=2)=CC=1>>[Cl:46][C:47]1[CH:59]=[CH:58][C:50]2[N:51]([CH:55]([CH3:57])[CH3:56])[C:52]([S:54][C:2]3[C:3](=[O:23])[O:4][C:5]([CH2:14][CH2:15][CH2:16][CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)([CH:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)[CH2:6][C:7]=3[OH:8])=[N:53][C:49]=2[CH:48]=1

Participants

5

Reactant 4

HCID 575272693-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-oneHCID 58762681HCID 58762681, compoundHCID 178456613HCID 178456613, compoundHCID 1785279605-pyridin-4-yl-1H-1,2,4-triazole-3-thiol

Product 1

HCID 58762495HCID 58762495, compound

Procedure

The title compound was prepared analogously to Example C(4), where 3-Chloro-6-(3-cyclohexyl-propyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one (described in Step 2 of example C(30) was substituted in place of 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one and 5-Chloro-1-isopropyl-2-mercapto benzimidazole was substituted in place of 5-Pyridin-4-yl-4H-[1,2,4]triazole-3-thiol of that example.

Sources & evidence

ORD record
ord-5cf0b1277a0f45d381c1772fdf890819
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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