3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one → HCID 178519118, compound

HRID 858814Notes

Reaction equation

HRID 858814 reaction equation
Cl[C:2]1[C:3](=[O:24])[O:4][C:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)([CH:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:6][C:7]=1[OH:8].ClC1C(=O)OC(CCC2CCCCC=2)(C2CCCC2)CC=1O.ClC1C=CC2N(C(C)C)C(S)=NC=2C=1.[N:61]1[CH:66]=[CH:65][C:64]([C:67]2[NH:68][C:69]([SH:72])=[N:70][N:71]=2)=[CH:63][CH:62]=1>>[CH:18]1([CH2:17][CH2:16][CH2:15][CH2:14][C:5]2([CH:9]3[CH2:13][CH2:12][CH2:11][CH2:10]3)[O:4][C:3](=[O:24])[C:2]([S:72][C:69]3[NH:68][C:67]([C:64]4[CH:65]=[CH:66][N:61]=[CH:62][CH:63]=4)=[N:71][N:70]=3)=[C:7]([OH:8])[CH2:6]2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

5

Reactant 4

HCID 575272693-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-oneHCID 57527275HCID 57527275, compoundHCID 178456613HCID 178456613, compoundHCID 1785279605-pyridin-4-yl-1H-1,2,4-triazole-3-thiol

Product 1

HCID 178519118HCID 178519118, compound

Procedure

The title compound was prepared analogously to Example C(4), where 3-Chloro-6-(4-cyclohexyl-butyl)-6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one (described in Step 2 of example C(32) was substituted in place of 3-Chloro-6-(2-cyclohex-1-enyl-ethyl)6-cyclopentyl-4-hydroxy-5,6-dihydro-pyran-2-one and 5-Chloro-1-isopropyl-2-mercapto benzimidazole was substituted in place of 5-Pyridin-4-yl-4H-[1,2,4]triazole-3-thiol of that example.

Sources & evidence

ORD record
ord-c60b5f89de9849a88026b127480ad8c2
Source dataset
uspto-grants-2006_12
Patent number
US07148226B2

Reaction notes

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