Hydrochloric Acid → (R)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid

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A solution of 3.7 mmol of (R)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester in 77 ml of dioxane was treated with 8.64 ml of hydrochloric acid (37%). The mixture was heated at 52° C. for 18 h in a closed flask. The solution was evaporated under reduced pressure to yield the crude acid as a yellowish solid. The crude acid was triturated at −5° C. in 10 ml of ethyl acetate. The solid was collected on a filter funnel and then dried under high vacuum to yield (R)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid as a white solid; MS: m/e=330 (M+H)+.

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