HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl (S)-2-amino-6-methyl-6-nitroheptanoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (S)-2-amino-6-methyl-6-nitroheptanoic acid | HCID 9834264 | — |
| Product | methyl (S)-2-amino-6-methyl-6-nitroheptanoate hydrochloride | HCID 9813744 | — |
Reaction Steps
(S)-2-Amino-6-methyl-6-nitroheptanoic acid (20.5 g) was dissolved in methanol (177 ml) and thionyl chloride (7.34 ml) was gently added dropwise under ice-cooling. The mixture was refluxed under heating for 2.5 h, and methanol was concentrated under reduced pressure to give the objective compound (21.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07148371B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-101ed5cc55ee471ba26e716df485ad96 |
| Source note | uspto-grants-2006_12 |