8-Quinolinol, 2-methoxy- → 2-Methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline

HRID 858980Notes

Reaction equation

HRID 858980 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[CH3:18][O:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[C:23]([OH:30])[CH:24]=[CH:25][CH:26]=2)[N:21]=1>>[CH3:18][O:19][C:20]1[CH:29]=[CH:28][C:27]2[C:22](=[C:23]([O:30][C:2]3[CH:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=4)[N:5]=[CH:4][N:3]=3)[CH:24]=[CH:25][CH:26]=2)[N:21]=1

Participants

3

Reactant 2

HCID 7627198-Quinolinol, 2-methoxy-HCID 167478374-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

Product 1

HCID 167482102-Methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline

Procedure

The title compound was prepared from 4-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidine (Example 2(a), Method A) and 2-methoxy-quinolin-8-ol (prepared according to Ataev, A; et al. Teoreticheskaya i Eksperimental'naya Khimya 1980, 16(2), 243–249) under the conditions of Example 6. Mp: 158.5–161° C. MS (ESI, pos. ion) m/z: 398 (M+1).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-b3c9d659ca1846a4909cd724736d2761
Source dataset
uspto-grants-2006_12
Patent number
US07148221B2

Reaction notes

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