4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine → 8-({6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline

HRID 858981Notes

Reaction equation

HRID 858981 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][C:26]=2[OH:28])[CH:21]=[CH:20][N:19]=1>>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([O:28][C:26]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:27]=3[CH:18]=[N:19][CH:20]=[CH:21]4)[CH:7]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 167478374-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidineHCID 1354417118-Hydroxyisoquinoline

Product 1

HCID 103843168-({6-[4-(Trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline

Procedure

The title compound was prepared from 4-chloro-6-(4-trifluoromethyl-phenyl)-pyrimidine (Example 2(a), Method A) and isoquinolin-8-ol (MonomerChem) under the conditions of Example 6. Mp: 194–195° C. MS (ESI, pos. ion) m/z: 368.2 (M+1).

Sources & evidence

ORD record
ord-6a690a8639be41fe9fd8006b340248bd
Source dataset
uspto-grants-2006_12
Patent number
US07148221B2

Reaction notes

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