Methyl iodide → HCID 21865348, compound

Participants

Reaction Steps

To a mixture of 8-[6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-1H-quinoxalin-2-one, (Example 32(e)), (0.10 g, 0.26 mmol) and K2CO3 (0.043 g, 0.31 mmol, Aldrich) in DMF (1 mL) was added iodomethane (0.019 mL, 0.31 mmol, Aldrich). The mixture was stirred at room temperature for 20 h, diluted with water and extracted with 25% i-PrOH/CHCl3 (3×). After being concentrated in vacuum, the residue was purified by flash chromatography (0→2% 2M NH3 in MeOH/CH2Cl2) to afford the title compound as an off-white amorphous solid. Mp: 158° C. MS (ESI, pos. ion) m/z: 399 (M+1).

Provenance & Evidence