HRID859041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1514430

tert-Butyl 4-formylpiperidine-1-carboxylate

C11H19NO3

结构：CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4N)ncn3)cccc2s1

HCID21865046

未命名化合物

PRODUCTS

生成物

结构：CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4NCC4CCN(C(=O)OC(C)(C)C)CC4)ncn3)cccc2s1

HCID21865131

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from N-{4-[6-(2-amino-4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl}-acetamide (Example 151) and N-Boc-4-piperidinylcarboxaldehyde according the procedure described in Example 159. MS(ESI, pos. ion) m/z: 643 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-071a2fdc665143e6b1088f8ebf0a4b6b
来源数据集: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07148221B2
来源说明: uspto-grants-2006_12

反应 SMILES

[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]1[N:17]=[CH:16][N:15]=[C:14]([O:18][C:19]2[C:24]3[N:25]=[C:26]([NH:28][C:29](=[O:31])[CH3:30])[S:27][C:23]=3[CH:22]=[CH:21][CH:20]=2)[CH:13]=1.[CH3:32][C:33]([O:36][C:37]([N:39]1[CH2:44][CH2:43][CH:42]([CH:45]=O)[CH2:41][CH2:40]1)=[O:38])([CH3:35])[CH3:34]>>[C:33]([O:36][C:37]([N:39]1[CH2:44][CH2:43][CH:42]([CH2:45][NH:1][C:2]2[CH:7]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:5]=[CH:4][C:3]=2[C:12]2[CH:13]=[C:14]([O:18][C:19]3[C:24]4[N:25]=[C:26]([NH:28][C:29](=[O:31])[CH3:30])[S:27][C:23]=4[CH:22]=[CH:21][CH:20]=3)[N:15]=[CH:16][N:17]=2)[CH2:41][CH2:40]1)=[O:38])([CH3:35])([CH3:32])[CH3:34]