HCID 18619139, compound → HCID 18619165, compound

HRID 859174Notes

Reaction equation

HRID 859174 reaction equation
[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:15])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=1

Participants

5

Reactant 2

HCID 18619139HCID 18619139, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 18619165HCID 18619165, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (5-nitropyridin-2-yloxy)acetic acid methyl ester (0.23 g, 1.08 mmol) in methanol (30 mL) was added palladium on activated carbon (10 wt. %, 0.20 g) and the solution was blanketed with hydrogen at atmospheric pressure. After 4 h the solids were removed by filtration and the volatiles were removed to yield 0.16 g (82%) of (5-amino-pyridin-2-yloxy)-acetic acid methyl ester as an oil that was used without further purification.

Workup

  1. customAfter 4 h the solids were removed by filtration
  2. customthe volatiles were removed

Sources & evidence

ORD record
ord-1ab6c00ce53f49e1ac0ff21019040da3
Source dataset
uspto-grants-2006_12
Patent number
US07151112B1

Reaction notes

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