Bromine → HCID 58763925, compound

HRID 859179Notes

Reaction equation

HRID 859179 reaction equation
[Br:1]Br.[CH2:3]([O:5][C:6]([C:8]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[N:10]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[N:9]=1)=[O:7])[CH3:4]>C(O)(=O)C>[CH2:3]([O:5][C:6]([C:8]1[C:12]([Br:1])=[C:11]([C:13]2[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=2)[N:10]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[N:9]=1)=[O:7])[CH3:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 69148316HCID 69148316, compound

Product 1

HCID 58763925HCID 58763925, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (15 ml, 294 mmol) was added in one portion to a cooled (ice/water bath) stirred solution of 5-(4-chlorophenyl)-1-(2-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (26.6 g, 73.6 mmol) in acetic acid (300 ml). After 45 minutes, the reaction was concentrated in vacuo, the solids slurried in diethyl ether (100 ml), filtered and dried in vacuo to afford the title compound (I-1a) as a light-yellow colored solid, 29.6 g.

Workup

  1. concentrationthe reaction was concentrated in vacuo
  2. filtrationfiltered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7603991033f04f5f845ad0beeefb0255
Source dataset
uspto-grants-2006_12
Patent number
US07151097B2

Reaction notes

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