Hydrochloric Acid → HCID 131726168, compound

Participants

Reaction Steps

A solution of 5-(4-chlorophenyl)-1-(2-chlorophenyl)-4-[2-(2,2,2-trifluoroethylamino)-ethoxy]-1H-pyrazole-3-carboxylic acid ethyl ester I-1g (48 mg, 0.1 mmol) and 6 N aqueous KOH (0.1 ml) in ethanol (1 ml) was heated at 50° C. for 2 hours. The reaction solution was cooled, acidified with concentrated aqueous hydrochloric acid, and concentrated in vacuo to a solid. These solids were slurried with ethanol, filtered and the remaining mass was washed with additional portions (2×) of ethanol. The combined filtrates were concentrated in vacuo to afford the title compound (I-1h), which was taken on the next step without further purification.

Provenance & Evidence