Ethanolamine → HCID 26188900, compound

HRID 859187Notes

Reaction equation

C(O[C:4](=[O:9])[C:5]([F:8])([F:7])[CH3:6])C.[CH2:10]([CH2:12][NH2:13])[OH:11]>>[F:8][C:5]([F:7])([CH3:6])[C:4]([NH:13][CH2:12][CH2:10][OH:11])=[O:9]

Participants

Reactant 2

HCID 700Ethanolamine

HCID 2761188Ethyl 2,2-difluoropropanoate

Product 1

HCID 26188900HCID 26188900, compound

Procedure

2,2-Difluoro-propionic acid ethyl ester I-3a (10.1 g, 70 mmol) was added dropwise to stirred, cooled (0° C.) ethanolamine (4.4 ml, 70 mmol) and the resulting solution was allowed to stir at ambient temperature for 4 hours. Concentration of the reaction mixture in vacuo afforded the title compound (I-3b) as a solid, 11.2 g.

Workup

stirringto stir at ambient temperature for 4 hours

Sources & evidence

ORD record: ord-ff57f75422ba4c908642cf8113476526
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07151097B2

Reaction notes

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