Hydrochloric Acid → HCID 58763940, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2-tert-butoxycarbonylaminoethylamino)-1-(2-chlorophenyl)-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (I-4b, 900 mg) in ethanol (50 ml) at room temperature was added 1 N KOH (25 ml). The reaction mixture was heated at 50° C. for 2 hours, cooled to room temperature, diluted with saturated aqueous NaCl, and acidified to pH 3 with 3N HCl. The aqueous solution was extracted with EtOAc (2×) and the combined organic extracts were dried and concentrated in vacuo to give the product I-4c as an amorphous glass (879 mg): +ES MS (M+1) 491.5.

Provenance & Evidence