Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Itaconic acid | HCID 811 | — |
| Reactant | 4-Benzyloxyaniline | HCID 22860 | — |
| Product | STK087815 | HCID 2968114 | 96.2% |
Reaction Steps
18.8 g (94.4 mmol) of 4-benzyloxyaniline are mixed with 12.28 g (94.4 mmol) itaconic acid. The solid mixture is heated to 130° C. After 20 min the molten material solidifies. After cooling, the resulting solid is triturated with ethyl acetate to yield 28.26 g (96% of theory) of (RS)-1-(4-benzyloxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid as a greyish solid. MS: m/e=311 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07151111B2 |
|---|
| Source dataset | uspto-grants-2006_12 |
|---|
| ORD ID | ord-d2c1f1d1ab794804bd1e99d02e1040b9 |
|---|
| Source note | uspto-grants-2006_12 |
|---|
