HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Benzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Benzylamine | HCID 7504 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
Step 1 The first step of Scheme 1 is accomplished by treating Compound i (Ref. U.S. Ser. No. 60/533,335 filed Dec. 29, 2003) with a benzyl amine, or a substituted benzyl amine, in the presence of a tertiary base such as triethylamine, or diisopropylethylamine, in an anhydrous solvents such as THF, DMF, DMA, acetonitrile or chloroform, at a temperature between about 20° C. to about 120° C., to give an ammonium salt, Compound ii.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151176B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-770c0e153ac1441fa2ab05fe15351e71 |
| Source note | uspto-grants-2006_12 |