p-Ethynyltoluene → HCID 69592839, compound

HRID 859289Notes

Reaction equation

HRID 859289 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[C:19]1([CH3:27])[CH:24]=[CH:23][C:22]([C:25]#[CH:26])=[CH:21][CH:20]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:26]#[C:25][C:22]2[CH:23]=[CH:24][C:19]([CH3:27])=[CH:20][CH:21]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 13018p-EthynyltolueneHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

Product 1

HCID 69592839HCID 69592839, compoundYield 89.7%

Procedure

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) (728 mg, 2.0 mmol) and 4-tolylacetylene (349 mg, 3.0 mmol) according to the general procedure F. Obtained as a yellow solid (632 mg).

Sources & evidence

ORD record
ord-957eda221ada41f69f1f951333151fb1
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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