HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → (2-Nitro-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | tert-Butyl (4-ethynyl-2-nitrophenyl)carbamate | HCID 23554338 | — |
| Product | (2-Nitro-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester | HCID 69592841 | 62.3% |
Reaction Steps
Prepared from (4-ethynyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example F2) (262 mg, 1.00 mmol) and 2-bromothiazole (0.14 mL, 1.50 mmol) according to the general procedure F. Obtained as a yellow solid (215 mg). MS (ISN) 344 [(M−H)−]; mp 137° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151098B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-209d4a73d4f045cba62bc2f62e80be08 |
| Source note | uspto-grants-2006_12 |