(4-Benzoyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester → Carbamic acid,(2-amino-4-benzoylphenyl)-,1,1-dimethylethyl ester

HRID 859321Notes

Reaction equation

HRID 859321 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][C:9]=1[N+:22]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592825(4-Benzoyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 69592848Carbamic acid,(2-amino-4-benzoylphenyl)-,1,1-dimethylethyl esterYield 105%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (4-benzoyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example D1) (280 mg, 0.82 mmol) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a yellow foam (269 mg).

Sources & evidence

ORD record
ord-bc336cbca2fc42b081f9f95e9b20a416
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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