(2-Nitro-4-pyridin-4-yl-phenyl)-carbamic acid tert.-butyl ester → Tert-butyl 2-amino-4-(pyridin-4-yl)phenylcarbamate

HRID 859325Notes

Reaction equation

HRID 859325 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:10][C:9]=1[N+:20]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592796(2-Nitro-4-pyridin-4-yl-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 59737204Tert-butyl 2-amino-4-(pyridin-4-yl)phenylcarbamate

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (2-nitro-4-pyridin-4-yl-phenyl)-carbamic acid tert.-butyl ester (Example C11) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a light grey powder (305 mg).

Sources & evidence

ORD record
ord-404ec4b7a9c14259a32ed94e8ed25a21
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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