Tert-butyl 4-isopropyl-2-nitrophenylcarbamate → Tert-butyl 2-amino-4-isopropylphenylcarbamate

HRID 859341Notes

Reaction equation

HRID 859341 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:16])[CH3:15])=[CH:10][C:9]=1[N+:17]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:15])[CH3:16])=[CH:10][C:9]=1[NH2:17])([CH3:3])([CH3:2])[CH3:4]

Participants

3

Reactant 1

HCID 66865138Tert-butyl 4-isopropyl-2-nitrophenylcarbamate

Product 1

HCID 66864908Tert-butyl 2-amino-4-isopropylphenylcarbamate

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from (4-isopropyl-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A2) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a white solid (12.59 g).

Sources & evidence

ORD record
ord-6ef6f8456c844b57a733faf4f837a3ba
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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