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3-(1H-imidazol-1-yl)benzoic acid → tert-Butyl 3-(3-(1H-imidazol-1-yl)phenyl)-3-oxopropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(1H-imidazol-1-yl)benzoic acid | HCID 2795544 | — |
| 反応物 | Methyl 3-(1H-imidazol-1-YL)benzoate | HCID 22224641 | — |
| 反応物 | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| 溶媒 | Sulfuric acid methanol | HCID 18363649 | — |
| 生成物 | tert-Butyl 3-(3-(1H-imidazol-1-yl)phenyl)-3-oxopropanoate | HCID 69592789 | — |
反応手順
Prepared from methyl 3-(1H-imidazol-1-yl)benzoate [prepared from 3-(1H-imidazol-1-yl)benzoic acid (J. Med. Chem. 1987, 30, 1342; CAS-No. [108035-47-8] by refluxing in conc. H2SO4/MeOH] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange-brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07151098B2 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-2016da0430264a6585ca86904c3bf78b |
| 出典メモ | uspto-grants-2006_12 |