HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic anhydride → 3-Oxo-3-(3-[1,2,4]triazol-1-yl-phenyl)-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | Methyl 3-(1H-1,2,4-triazol-1-YL)benzoate | HCID 22224836 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Solvent | TFA acetone | HCID 86586799 | — |
| Product | 3-Oxo-3-(3-[1,2,4]triazol-1-yl-phenyl)-propionic acid tert-butyl ester | HCID 69592807 | — |
Reaction Steps
The 3-oxo-3-(3-[1,2,4]triazol-1-yl-phenyl)-propionic acid tert.-butyl ester was prepared from 3-[1,2,4]triazol-1-yl-benzoic acid methyl ester [CAS-No. 167626-27-9] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Prepared from (Example H6) by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a yellow solid (539 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151098B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-68c7ae2ff62e448584645e100a8d34a8 |
| Source note | uspto-grants-2006_12 |