Ethyl 3-(3-cyanophenyl)-3-oxopropanoate → {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-iodo-phenyl}-carbamic acid tert.-butyl ester

HRID 859381Notes

Reaction equation

HRID 859381 reaction equation
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[NH2:15])([CH3:4])([CH3:3])[CH3:2].C([O:19][C:20](=O)[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=[O:23])C>>[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[NH:15][C:20](=[O:19])[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([C:30]#[N:31])[CH:25]=1)=[O:23])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 11622629Ethyl 3-(3-cyanophenyl)-3-oxopropanoateHCID 69592774(2-Amino-4-iodo-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 86587990{2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-iodo-phenyl}-carbamic acid tert.-butyl esterYield 88%

Procedure

Prepared from (2-amino-4-iodo-phenyl)-carbamic acid tert.-butyl ester (Example G1) (900 mg, 2.7 mmol) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester (880 mg, 4.1 mmol) according to the general procedure K. Obtained as a yellow solid (1.2 g).

Sources & evidence

ORD record
ord-cd4c8a057bc944fca8714df1aa5cd9f4
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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