2,2-Dimethyl-6-(3-trifluoromethyl-phenyl)-[1,3]dioxin-4-one → HCID 86588011, compound

HRID 859403Notes

Reaction equation

HRID 859403 reaction equation
[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:28])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:36][C:35](=O)[CH:34]=[C:33]([C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([C:44]([F:47])([F:46])[F:45])[CH:39]=2)[O:32]1>>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH:28][C:35](=[O:36])[CH2:34][C:33](=[O:32])[C:38]1[CH:43]=[CH:42][CH:41]=[C:40]([C:44]([F:45])([F:47])[F:46])[CH:39]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222247162,2-Dimethyl-6-(3-trifluoromethyl-phenyl)-[1,3]dioxin-4-oneHCID 69592766Carbamic acid,[2-amino-4-[6-(phenylmethoxy)-3-pyridinyl]phenyl]-,1,1-dimethylethyl ester

Product 1

HCID 86588011HCID 86588011, compoundYield 67.6%

Procedure

Prepared from [2-amino-4-(6-benzyloxy-pyridin-3-yl)-phenyl]-carbamic acid tert.-butyl ester (Example G30) (203 mg, 0.52 mmol) and 2,2-dimethyl-6-(3-trifluoromethyl-phenyl)-[1,3]dioxin-4-one (Example J5) (150 mg, 0.55 mmol) according to the general procedure K. Obtained as an off-white solid (213 mg).

Sources & evidence

ORD record
ord-823fb7a1c6b14df1869f4b0240ee98ee
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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