Ethyl 3-(3-cyanophenyl)-3-oxopropanoate → {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4'-trifluoromethoxy-biphenyl-4-yl}-carbamic acid tert.-butyl ester

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 3-(3-cyanophenyl)-3-oxopropanoate	HCID 11622629	—
Reactant	Carbamic acid,[3-amino-4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-,1,1-dimethylethyl ester	HCID 69592772	—
Product	{3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4'-trifluoromethoxy-biphenyl-4-yl}-carbamic acid tert.-butyl ester	HCID 86588012	—

Reaction Steps

Prepared from (3-amino-4′-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G27) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester (Pol. J. Chem. 1978, 25) according to the general procedure K. Obtained as a brown semisolid (94 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07151098B2
Source dataset	uspto-grants-2006_12
ORD ID	ord-0033137e76264cd8b287a2824e820de3
Source note	uspto-grants-2006_12