HRID859421

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2ccnc(-n3ccnc3)c2)O1

HCID22224862

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1N

HCID69486641

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1NC(=O)CC(=O)c1ccnc(-n2ccnc2)c1

HCID86588029

未命名化合物

PROCEDURE

实验过程

Prepared from [2-amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example G33) and 6-(2-imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J14) according to the general procedure K. Obtained as a brown solid (284 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b388fefd0a21492d97069bee1a2f5d6a
来源数据集: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07151098B2
来源说明: uspto-grants-2006_12

反应 SMILES

[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH2:23])([CH3:4])([CH3:3])[CH3:2].[N:25]1([C:30]2[CH:35]=[C:34]([C:36]3[O:41]C(C)(C)[O:39][C:38](=O)[CH:37]=3)[CH:33]=[CH:32][N:31]=2)[CH:29]=[CH:28][N:27]=[CH:26]1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)=[CH:10][C:9]=1[NH:23][C:38](=[O:39])[CH2:37][C:36]([C:34]1[CH:33]=[CH:32][N:31]=[C:30]([N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)[CH:35]=1)=[O:41])([CH3:4])([CH3:2])[CH3:3]