HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile → {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-2',4'-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile | HCID 11736337 | — |
| Reactant | Carbamic acid,(3-amino-2',4'-difluoro[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester | HCID 69592785 | — |
| Product | {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-2',4'-difluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588070 | — |
Reaction Steps
Prepared from (3-amino-2′,4′-difluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G43) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) according to the general procedure K. Obtained as an orange oil (95 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151098B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-adcfe6d2ebce4efb8318a0833c41264b |
| Source note | uspto-grants-2006_12 |