HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86587994 | HCID 86587994 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one | HCID 22224695 | 78.2% |
Reaction Steps
Prepared from {2-[3-(3-iodo-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester (Example K7) (871 mg, 1.5 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (542 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151098B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-49a0a8ea4abc49b1847b4c6b210feda0 |
| Source note | uspto-grants-2006_12 |