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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 859484Generated: October 30, 2026

Trifluoroacetic acid → HCID 22224796, compound

https://huagongshe.com/reaction/859484

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrileHCID 11736337—
ReactantHCID 69592878HCID 69592878—
SolventDichloromethaneHCID 6344—
ProductHCID 22224796HCID 22224796—

Reaction Steps

Prepared from (3-amino-2′-methoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G10) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light green powder (30 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07151098B2
Source datasetuspto-grants-2006_12
ORD IDord-11b300b7986e43a2a4bacdc60cc5b769
Source noteuspto-grants-2006_12