HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Phenyl-4-thiophen-2-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2,2-Dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-one | HCID 22224708 | — |
| Reactant | N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester | HCID 57717454 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Phenyl-4-thiophen-2-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22224745 | 59.5% |
Reaction Steps
Prepared from (3-amino-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G9) (69 mg, 0.243 mmol) and 2,2-dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-one (Example J1) (54 mg, 0.257 mmol) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a brown solid (46 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07151098B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-9f20f6da57e34806b908b0ac0b0b05b9 |
| Source note | uspto-grants-2006_12 |