Acetic Anhydride → N-{3-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-phenyl}-acetamide

HRID 859533Notes

Reaction equation

HRID 859533 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:14][C:13](=[O:15])[NH:12][C:11]3[CH:16]=[C:17]([C:20]4[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=4)[CH:18]=[CH:19][C:10]=3[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][C:28](OC(C)=O)=[O:29]>CC(O)=O>[F:26][C:23]1[CH:22]=[CH:21][C:20]([C:17]2[CH:18]=[CH:19][C:10]3[N:9]=[C:8]([C:4]4[CH:3]=[C:2]([NH:1][C:28](=[O:29])[CH3:27])[CH:7]=[CH:6][CH:5]=4)[CH2:14][C:13](=[O:15])[NH:12][C:11]=3[CH:16]=2)=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 222245874-(3-Amino-phenyl)-8-(4-fluoro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Product 1

HCID 22224605N-{3-[7-(4-Fluoro-phenyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-phenyl}-acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared from 4-(3-amino-phenyl)-8-(4-fluoro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 70) by treatment with Ac2O in HOAc at 80° C. Obtained as a light yellow solid (9 mg).

Sources & evidence

ORD record
ord-8752d0673df94cfb9aef738d2d64ff69
Source dataset
uspto-grants-2006_12
Patent number
US07151098B2

Reaction notes

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