HCID 131726169, compound → HCID 58764112, compound

Participants

Reaction Steps

To a solution of 6-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-3-ethyl-phenyl]-2-cyclopentyl-2-hydroxy-but-3-ynyl}-2,2-dimethyl-[1,3]dioxin-4-one (1.0 g) in EtOH (50 mL) was added Pd(OH)2 (20 wt %, 100 mg). The reaction was stirred under H2 atmosphere for 15 hours. The reaction was filtered through a pad of celite and the solvent was removed under reduced pressure to afford the desired product. 1H NMR (300 MHz, CDCl3): δ 1.19 (t, J=7.5 Hz, 3 H), 1.43–1.69 (m, 8 H), 1.71 (s, 6 H), 1.79–1.85 (m, 2 H), 2.05–2.16 (m, 1 H), 2.27 (s, 3 H), 2.44–2.66 (m, 6 H), 5.37 (s, 1 H), 6.89–6.95 (m, 2 H), 7.04–7.08 (m, 1 H).

Provenance & Evidence