Hydrochloric Acid → HCID 69058230, compound

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Reaction Steps

tert-Butyl 4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)-2-ethylbenzylcarbamate (35 mg, 0.06 mmol, example A(126)) was dissolved in dichloromethane (1 mL) and 4N HCl in dioxane (0.5 mL) and stirred at room temperature 2 h. The solution was concentrated to give an off-white solid (30 mg, 96%). 1H NMR (300 MHz, CDCl3): δ ppm 1.14 (t, J=7.54 Hz, 3 H) 1.37–1.49 (m, 1 H) 1.52–1.66 (m, 6 H), 1.67–1.77 (m, 2 H) 2.05–2.16 (m, 2 H) 2.58 (s, 4 H) 2.60–2.70 (m, 6 H) 2.74–2.80 (m, 1 H), 3.80 (d, J=14.51 Hz, 2 H) 4.02 (q, J=5.78 Hz, 2 H) 7.07 (s, 1 H) 7.13 (s, 1 H) 7.16–7.21 (m, 1 H) 7.32 (d, J=7.72 Hz, 1 H) 8.15 (s, 3 H). MS (ESI): 504 (M+H)+.

Provenance & Evidence