HCID 15900019, Verbindung → 4-Bromo-2-ethylbenzaldehyde

HRID 859687Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 859687
[NH+]1([O-])CCOCC1.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[C:11]([CH2:17][CH3:18])[CH:10]=1>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[O:16])=[C:11]([CH2:17][CH3:18])[CH:10]=1

Komponenten

5

Edukt 2

HCID 15900019HCID 15900019, VerbindungHCID 587642724-bromo-2-ethylbenzenemethanol

Produkt 1

HCID 532567934-Bromo-2-ethylbenzaldehydeAusbeute 110,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178419074HCID 178419074, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Morpholine-N-oxide (5.0 g, 43 mmol) was stirred in dichloromethane (30 mL) over 3A sieves 30 min under N2 atmosphere. (4-Bromo-2-ethyl-phenyl)-methanol (3.1 g, 14.4 mmol), then tetrapropylammonium perruthenate (250 mg, 0.72 mmol) was added. The solution was stirred 2 h then filtered through a plug of silica. The silica was washed with 30% ethyl acetate in hexanes, and the organics were pooled. The solution was concentrated in vacuo to give a light yellow oil (3.4 g).

Aufarbeitung

  1. filtrationthen filtered through a plug of silica
  2. washThe silica was washed with 30% ethyl acetate in hexanes
  3. concentrationThe solution was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7a2cbfa3c43f40a4ab72e9f85474da38
Quelldatensatz
uspto-grants-2006_12
Patentnummer
US07151105B2

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