Sodium Hydroxide → HCID 58764043, compound

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Reaction Steps

Methyl 4-[2-(2-cyclopentyl-4,6-dioxotetrahydro-2H-pyran-2-yl)ethyl]-2-fluorobenzoate (example B(5)) (300 mg) was treated with 4N NaOH (10 ml) and stirred for 4 hrs at room temperature. The mixture was then acidified with 1N HCl (20 ml) and the product was extracted with ethyl acetate (2×20 ml). The combined organic layers were dried over magnesium sulfate and concentrated to a solid. The solid was recrystallised from diethyl ether to afford the title compound as a white solid (120 mg). 1H NMR (300 MHz, MeOD): δ 1.38–2.30 (m, 11 H), 2.80–3.12 (m, 6 H), 6.91 (d, J=7.19 Hz, 1 H), 7.17 (m, 1 H), 7.86 (d, J=719 Hz, 1 H)

Provenance & Evidence