3-[5-Chloro-6-(cyano-dimethyl-methyl)-pyridin-3-yl]-acrylic acid ethyl ester → 4-(4-Ethoxycarbonyl-butyl)-piperidine-1-carboxylic acid tert-butyl ester

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Reaction Steps

The title compound was prepared analogously to step 4 of example B(29)where 4-(4-ethoxycarbonyl-but-3-enyl)-piperidine-1-carboxylic acid tert-butyl ester from step 2 above, was substituted in place of 3-[5-chloro-6-(cyano-dimethyl-methyl)-pyridin-3-yl]-acrylic acid ethyl ester of that example. 1H NMR (400 MHz, CDCl3): δ 0.99–1.12 (m, 2H), 1.23–1.40 (m, 8H), 1.45 (s, 9H), 1.56–1.66 (m, 4H), 2.27–2.32 (m, 2H), 2.61–2.70 (m, 2H), 4.04–4.16 (m, 4H). ESIMS (MH+): 314.

Provenance & Evidence